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Typical interactions with calcineurin inhibitors

Typical interactions with calcineurin inhibitors The calcineurin inhibitors (CNIs), tacrolimus and ciclosporin, both metabolised by the enzyme CYP3A4 and P-glycoprotein, would be the first-line immunosuppressant medicines used to stop organ rejection 15. Drug–drug interactions can result in significant alterations in bloodstream plasma amounts and mainly happen when medications which are either inducers or inhibitors associated …

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